View abstract. J Ethnopharmacol 1999;64:91-3. Ashwagandha dosing may vary by brand or reason for use. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Read more: How Vegans Can Get All Their Nutrients (Without Taking Supplements). It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. This herbal medicine term means that this substance is thought to help the body respond to mental and physical stress and to restore normal emotional and physical body function. Mixing tyramine and MAOI antidepressants can result in headache, nausea, anxiety, dangerously high blood pressure and even hemorrhagic stroke. J Diet Suppl. J Clin Psychiatry. Acta Oncol. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. It is commonly used for stress. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that. 1985;23(4):177-183. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. This is one of the more common food-drug reactions. Varying levels of research have looked at the potential benefits of ashwagandha. Read our. Critical review of theWithania somnifera(L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. PLoS One. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Lu, L., Liu, Y., Zhu, W., Shi, J., Liu, Y., Ling, W., and Kosten, T. R. Traditional medicine in the treatment of drug addiction. View abstract. Always check with your doctor before you use a natural product. 2019;11(12):e6466. Phytother.Res 2010;24(1):129-135. J.Transl.Med. This product may cause you to be sleepy. In large amounts, any of these could potentially affect the way your body processes antidepressants. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. J Atten Disord 2010;14:281-91. View abstract. Ashwagandha can also interact with some medications and affect how they work. Therefore,it could theoretically increase the risk of hypoglycemia (i.e. 2021;272:113929. doi:10.1016/j.jep.2021.113929, Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. 1998;20(1):191-198. Take extra care if you are taking iron supplements. Fertil Steril 2010;94:989-96. IV. As this is a relatively new area of research, more vigorous studies are needed. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. Medically reviewed by Drugs.com. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Myxedema Coma. ; Vomiting and nausea. J Altern Complement Med. Phytother Res 1991;5:111-14. This information does not contain all possible interactions or adverse effects. You can also connect with Dr. Brian Staiger on LinkedIn. Tumori 8-31-1994;80(4):306-308. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. Anbalagan, K. and Sadique, J. If you are experiencing serious medical symptoms, please see the Herbal supplements can strongly affect the body. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. A total of 0 drugs are known to interact with ashwaganda. Adv Exp Med Biol. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Take extra care driving and doing tasks that you need to be alert for while taking this product. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? Some people may need to avoid taking Ashwagandha, however, including those who: Ashwagandha may be used for anxiety due to its perceived anti-inflammatory and antioxidant properties. . She founded the Fad Free Nutrition Blog and Nutricion al Grano websites and is based in Texas. View abstract. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. Serotonin syndrome can even result in death. 2017;14(6):599-612. doi:10.1080/19390211.2017.1284970, Tiwari S, Gupta SK, Pathak AK. Certain antidepressants may not be compatible with herbs or other natural ingredients in these products. Skinmed. 2021;51(4):363-365. If you take thyroid medicine, consult your doctor before using ashwagandha. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Available for Android and iOS devices. Durg S, Bavage S, Shivaram SB. It should not be confused with Physalis alkekengi, which is also referred to as winter cherry. Ashwagandha's leaves contain a compound that causes sleep induction and is used for treating insomnia. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Evid Based Complement Alternat Med. 2021;6(1):20. doi:10.3390/jfmk6010020, Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and safety of ashwagandha (Withania somnifera) root extract in insomnia and anxiety: a double-blind, randomized, placebo-controlled study. View abstract. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. J Obstet Gynaecol Res 2021. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. However, these results have not been proven in humans. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. 2013;2013:571420. Participants of this study received either a placebo or 300 milligrams of ashwagandha twice per day for eight weeks. Kulkarni RR, Patki PS, Jog VP, et al. Complement Ther Med 2016 Aug;27:25-9.View abstract. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. Davis L, Kuttan G. Suppressive effect of cyclophosphamide-induced toxicity by Withania somnifera extract in mice. Ashwagandha might increase the sedative effects of benzodiazepines, prescribed for conditions such as panic disorder and anxiety, and of barbiturates, primarily used for epilepsy. These side effects may be mild or severe. Long-term safety studies on ashwagandha are lacking. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). View abstract. Notably, ashwagandha doses typically do not exceed 1,000 milligrams per day for up to 12 weeks. 2005 - 2023 WebMD LLC, an Internet Brands company. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Gupta, S. K., Dua, A., and Vohra, B. P. Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications. As a general rule of thumb, never exceed the recommended dose of ashwagandha. View abstract. In this randomized, double-blind, placebo-controlled trial, 125 adult participants were randomized to either 300 milligrams per day of ashwagandha sustained release or a placebo for 90 days. Health Sci Rep 2022;5(4):e741. Biochem.Biophys.Res Commun. Levothyroxine is used to treat the following conditions: Hashimoto's disease. Read more: 15 Celebrities Who Struggle With Anxiety and Depression. There is no scientific evidence to support one supplement form over another, which means you should choose the one that best fits your lifestyle. Medicine (Baltimore). Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . View abstract. National Institutes of Health Office of Dietary Supplements. 2013;74(11):1076-83. View abstract. In the study, no adverse events were reported by participants who took the herb. Taking it with drugs that increase levels of thyroid hormone (e.g. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. These supplements may contain similar active ingredients or have potential uses that are like those of ashwagandha. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Underactive Thyroid. View abstract. . View abstract. View abstract. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Choudhary, M. I., Nawaz, S. A., ul-Haq, Z., Lodhi, M. A., Ghayur, M. N., Jalil, S., Riaz, N., Yousuf, S., Malik, A., Gilani, A. H., and ur-Rahman, A. Withanolides, a new class of natural cholinesterase inhibitors with calcium antagonistic properties. Headache. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. Neurol India 2009;57:166-71. 2008;6:14. View abstract. Its botanical name is Withania somnifera and it is also known as "Indian ginseng . Some don't work well with prescription medicines. Biogerontology. It may also interact with medications for these conditions. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. View abstract. Indian J Physiol Pharmacol. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. Monitor your blood pressure closely. Upton R, ed. Chauhan S, Srivastava MK, Pathak AK. However, tyramine-rich foods like cheeses, beer and other fermented products are dangerous for people taking MAOIs. View abstract. View abstract. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Ashwagandha appears to stimulate your endocrine system . J Ayurveda Integr Med. Kumar S, Bouic PJ, Rosenkranz B. Doses higher than that may interact with lexapro, or produce more pronounced effects. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. National Library of Medicines list Xanax is in the drug class benzodiazepines. Thyroid Suppression Test. 2020;34(5):1041-1059. Ashwagandha has no known moderate interactions with any drugs. The roots can be used topically as a poult. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. Ashwagandha may be toxic to the liver (hepatotoxic). Am J Ther 2023;30(1):e80-e83. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Devi, P. U., Sharada, A. C., and Solomon, F. E. In vivo growth inhibitory and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma. These severity listings are for informational use only. View abstract. Its effects on arterial blood pressure in anaesthetized dogs. View abstract. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. 2012;10(1):48-49. Animal research and one case study indicate that the herb might increase serum concentration of thyroid hormones, according to Ray Sahelian, a medical doctor who specializes in natural supplements. doi:10.1097/MD.0000000000017186, Pratte MA, Nanavati KB, Young V, Morley CP. View abstract. Ashwagandha might cause sleepiness and slowed breathing. View abstract. 2019;98(37):e17186. Davis, L. and Kuttan, G. Effect of Withania somnifera on DMBA induced carcinogenesis. ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. However, the review noted various limitations of the studies, including study design and potential bias. People who are pregnant or breastfeeding should not use ashwagandha. Taking ashwagandha along with medications that lower blood pressure might cause blood pressure to go too low. Those who took 600 milligrams per day of ashwagandha had better results than those in the 250 milligrams per day group, yet both groups saw improvements in stress. Consult a doctor before taking any medication. The ashwagandha root extract has been used for thousands of years as an herbal remedy in Ayurveda, the ancient Indian medical system. I was told that I had an allergic reaction to penicillin when I was a child. Do not use this product if you have stomach problems or ulcers. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Nutrients. View abstract. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. View abstract. From the study results, researchers concluded that ashwagandha improved memory and focus. Antioxidants (Basel). Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. Cureus. Studies are inconclusive, but ashwagandha may have immune-stimulating properties. Ashwagandha may have additive effects to certain drugs that are used for diabetes, high blood pressure, and low thyroid hormone, to name a few. Therefore, before using this product, tell your doctor or pharmacist of all the . Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. More are needed for more definitive results. . National Center for Complementary and Integrative Health. View abstract. J Funct Morphol Kinesiol. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Some of the more compelling potential uses of ashwagandha are outlined below. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Int Ayurvedic Med J 2013;1(5):1-7. Can You Take Lyrica And Flexeril Together? View abstract. Never start, stop or otherwise change your therapy before speaking with your provider. It is essential to talk to your healthcare provider before taking ashwagandha if you are taking any other substances. Am J Drug Alcohol Abuse 2009;35(1):1-11. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Some herbal supplements with antidepressant properties are safe to consume alongside medications. Curr Res Toxicol. View abstract. J Res Ayur Sid 1980;1:370-385. Ashwagandha is considered safe when taken daily for up to three months. We comply with the HONcode standard for trustworthy health information. However, there is concern that herbs like ashwagandha may have interactions that have . 2021;270:113766. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. 2001;75(2-3):165-168. Skinmed. Drug Metabol.Drug Interact. Another traditional use of ashwagandha in Ayurveda is for memory issues. Researchers from another review concluded that ashwagandha might be useful in conditions such as: Studies used in this review included human, animal, and lab research. Sehgal, V. N., Verma, P., and Bhattacharya, S. N. Fixed-drug eruption caused by ashwagandha (Withania somnifera): a widely used Ayurvedic drug. Association of l-DOPA with recovery following Ayurveda medication in Parkinson's Disease. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. In Ayurvedic medicine, ashwagandha has been used for centuries as an alternative treatment for anxiety. If you take a drug meant to suppress your immune systems, such as methotrexate or mycophenolate, they may have conflicting effects. O'Connor J, Lindsay K, Baker C, Kirby J, Hutchins A, Harris M. The impact of ashwagandha on stress, sleep quality, and food cravings in college students: quantitative analysis of a double-blind randomized control trial. 1996;35(1):95-100. Is Fish Oil Dangerous With Antidepressants? View abstract. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. Front Pharmacol 2022;13:901710. Cooley K, Szczurko O, Perri D, et al. Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. Ashwagandha may be able to help with insomnia. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. J Ethnopharmacol. Biomed Res Int 2015;2015:284154.View abstract. 2022;13(2):100510. doi:10.1016/j.jaim.2021.08.003, Gopukumar K, Thanawala S, Somepalli V, Rao TSS, Thamatam VB, Chauhan S. Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. Bhattacharya, S. K. and Muruganandam, A. V. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Compared to those who took the placebo, participants who took ashwagandha were found to have better visual memory, learning, and attention. We have said that the elements ashwagandha meds of will ashwagandha interact with diabetic meds cause, ashwagandha interact diabetic principle and ontology are the objects of our research. The liver damage never progressed to liver failure, and most cases were resolved within five months. View abstract. Safety and adverse events were also not well-reported in the studies used in the review. 2020;40(4):825-829. View abstract. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? View abstract. This interference is likely due to a similarity in chemical structure, according to Drugs.com. low blood sugar). Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. 2011;68(1):3-8. Is It Safe To Take Keflex (Cephalexin) With Birth Control? Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. Talk with a healthcare provider about the right ashwagandha dosage for your needs. of signs you need emergency medical attention or call 911. Nonetheless, additional large-scale, long-term studies would strengthen these findings. View abstract. Ahumada F, Aspee F, Wikman G, and et al. 2014;20(12):901-908. doi:10.1089/acm.2014.0177, Remenapp A, Coyle K, Orange T, et al. Be sure to confirm new supplements fit your dietary needs or preferences. J.Altern.Complement Med. Nutrients. 2021;57:102642. doi:10.1016/j.ctim.2020.102642, Bjrnsson HK, Bjrnsson ES, Avula B, et al. Hydroxyzine has moderate interactions with at least 207 different drugs. View abstract. Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Agarwal R, Diwanay S, Patki P, Patwardhan B. Taking high doses of ashwagandha may increase your risk of side effects. Memorial Sloan-Kettering Cancer Center: Ashwagandha, NYU Langone Medical Center: Ashwagandha Interactions You Should Know About, NYU Langone Medical Center: Benzodiazepines, "Therapeutic Drug Monitoring"; Herbal Supplements and Therapeutic Drug Monitoring; A. Dasgupta; April 2008, University of Maryland Medical Center: Anaphylaxis. Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions . Monitor your blood sugar closely. Ashwagandha has mild interactions with at least 29 different drugs. 2021;16(9):e0257843. One clinical trial evaluated how ashwagandha root extract affects memory and overall cognitive function. The study took place over 10 weeks, and participant results were assessed based on sleep onset latency, total sleep time, sleep efficiency, and wake after sleep onset. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. 2017 Jan;22(1):96-106 View abstract. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. Jardiance,Farxiga, Invokana), ACE-Inhibitors (e.g. 1992;30(3):169-172. The average vitamin or mineral should not affect your antidepressant's functionality or your health. Bjrnsson HK, Bjrnsson ES, Avula B, et al. The body naturally produces thyroid hormones. Chronic stress increases cortisol levels, leading to lower levels of T3 and T4. Effects of Withania somnifera in patients of schizophrenia: a randomized, double blind, placebo controlled pilot trial study. Ireland PJ, Hardy T, Burt AD, Donnelly MC. After eight weeks, statistically significant improvements were seen in both aerobic capacity and recovery for those who took ashwagandha. J Ethnopharmacol. No, that's not true all the time. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have. 2013;12(4):312-22. 2013;45(4):417-8. This holds true for ashwagandha. Some evidence suggests that ashwagandha may interact with: Before starting a new supplement, it is vital that you carefully read the ingredients list and nutrition facts panel to know which ingredients and how much of each ingredient is included in the supplement. Ashwagandha's cortisol-lowering effects may be responsible. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Ashwagandha may interact with certain drugs by enhancing or negating their actions. J Clin Lab Anal 2008;22:295-301. What Happens If I Take Too Much Ashwagandha? Cureus. Ashwagandha is an evergreen shrub that grows in Asia and Africa. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Ethnopharmacol 1991;33:91-5. 2012;34(3):255-62. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. Vitamin Keven in foods such as kale, lettuce, broccoli, and chickpeascan counteract a blood thinner's benefits. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. Hypothyroidism, After Thyroid Removal. No supplement is intended to treat, cure, or prevent disease. There aren't any specific antidiabetic drugs ashwagandha is known to interact with. The exact type of antidepressant you're taking will determine which foods, vitamins and supplements you should or should not ingest. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. 1965;9(3):127-136. Melissa Nieves, LND, RD, is a registered dietitian and licensed nutritionist who works as a bilingual telehealth dietitian. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. You can also use ashwagandha as an herbal tea. 2019;11(10):2362. doi:10.3390/nu11102362, Zhu C, Zhang Y, Wang T, et al. Dongre S, Langade D, Bhattacharyya S. Efficacy and safety of ashwagandha (withania somnifera) root extract in improving sexual function in women: a pilot study. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Created for people with ongoing healthcare needs but benefits everyone. Commonly prescribed SSRIs include sertraline (brand name Zoloft), paroxetine (Paxil), fluoxetine (Prozac) and citalopram (Celexa). J Ethnopharmacol. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. They should also be kept from direct sunlight and stored in their original bottle or container. View abstract. Take extra care if you are at a high risk for infection. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Most ashwagandha supplements are naturally vegan and gluten-free. Speak with a, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Mediterranean, Low-Fat Diets Are Best for Heart Problems, Least Amount of Exercise You Need to Stay Healthy, Nerve 'Pulse' Therapy May Help Ease Sciatica, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Attention deficit-hyperactivity disorder (ADHD), Chronic obstructive pulmonary disease (COPD), Antipsychotic-induced metabolic side effects, Think Your Child Has ADHD? View abstract. Taking ashwagandha along with sedative medications might cause too much sleepiness. Evid Based Complement Alternat Med. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera for cognitive dysfunction in bipolar disorder.